The half-life of amphetamine enantiomers differ and vary with urine pH.At normal urine pH, the half-lives of dextroamphetamine and levoamphetamine are 9–11 hours and 11–14 hours, respectively. Mephedrone When is it removed from blood and urine? ![]() The oral bioavailability of amphetamine varies with gastrointestinal pH it is well absorbed from the gut, and bioavailability is typically over 75% for dextroamphetamine.Amphetamine is a weak base with a pKa of 9.9 consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium.Ĭonversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is absorbed.Approximately 15–40% of amphetamine circulating in the bloodstream is bound to plasma proteins.Following absorption, amphetamine readily distributes into most tissues in the body, with high concentrations occurring in cerebrospinal fluid and brain tissue. As a member of the phenethylamine class, amphetamine is also chemically related to the naturally occurring trace amine neuromodulators, It is also the parent compound of its own structural class, the substituted amphetamines, which includes prominent substances such as bupropion, cathinone, MDMA, and methamphetamine. ![]() It’s one of the abuse drugs called “Amphetamines “Īmphetamine belongs to the phenethylamine class. Methamphetamine (MAMP) is a central nervous system stimulant.
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